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Cytidine deaminase (CD) catalyzed production of a key molnupiravir intermediate. In nature, CD catalyzes the hydrolysis of cytidine to uridine. CD was engineered to optimize its promiscuous hydroxyamination activity and provide direct access to N-hydroxycytidine from cytidine. A second lipase catalyzed 5′-acylation step delivers the target molnupiravir.
