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. 2022 Sep 21;43(1):99–114. doi: 10.1177/0271678X221119442

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Cerebral metabolism during hypercapnia prior to and following haemodilution. Pre-haemodilution mean and standard deviation data presented in red, post-haemodilution mean and standard deviation data presented in blue, with individual data overlaid for both. (a) cerebral arteriovenous O₂ content difference (Ca-jvO₂), (b) cerebral O₂ delivery (CDO₂), (c) O₂ extraction fraction (OEF), (d) cerebral metabolic rate of oxygen consumption (CMRO₂), (e) cerebral veno-arterial CO₂ content difference (Cjv-aCO₂), (f) cerebral washout of CO₂ content (CO₂ washout), (g) CO₂ insertion fraction (CO₂IF), and (h) cerebral metabolic rate of CO₂ production (CMRCO₂). Comparisons conducted using linear mixed-model analyses with Bonferroni adjustments for post-hocs. Asterisk (*) symbols indicate a difference from baseline (P<0.05) in both trials, obelisk (†) symbols indicate a difference from the +3 mm Hg stage (P < 0.05) in both trials, and double dagger (‡) symbols indicate a difference from the +6 mm Hg stage (P < 0.05) in both trials. While hash symbols (#) indicate a difference (P < 0.05) between pre and post haemodilution in all CVR stages. Where an interaction effect is indicated, these symbols refer to changes between stages within trials, and differences between trials within stages. N = 11 for A, C, E, and G; while n = 9 for b, d, f, and h.