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. Author manuscript; available in PMC: 2023 Jan 25.
Published in final edited form as: Cell Rep. 2022 Dec 27;41(13):111876. doi: 10.1016/j.celrep.2022.111876

Figure 3. Structure of bovine DNPEP.

Figure 3.

(A) Cryo-EM map of DNPEP.

(B) Structure of DNPEP. Twelve DNPEP monomers form a dodecamer with tetrahedral symmetry. Individual subunits are distinguished with different colors in both (A) and (B).

(C) Layout of DNPEP dimer. A DNPEP subunit can be divided into two units: a catalytic domain and a dimerization domain.

(D) Zoomed view of the Zn2+-binding site in a single DNPEP subunit. Two Zn2+ ions are found in each DNPEP subunit. The Zn2+ ions are colored cyan, cryo-EM densities (4σ) are depicted as blue meshes, and interacting residues are shown as gray spheres.