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. 2023 Jan 24;24:40. doi: 10.1186/s12864-023-09136-4

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — STRING-generated interaction network among selected enriched KEGG pathways. The network image shows interactions between proteins encoded by DEGs identified in the following KEGG molecular pathways: PI3K-Akt signaling pathway (ssc04151), prolactin signaling pathway (ssc04917), JAK-STAT signaling pathway (ssc04630), protein processing in endoplasmic reticulum (ssc04141) and phagosome (ssc04145). Clusters of genes/proteins within specific KEGG pathways are indicated in boxes and by corresponding colored nodes in the network image. Bold = up-regulated genes; Plain text = down-regulated genes in T20 vs CTL gilts. The thickness of the lines represents the confidence prediction of the interaction between 2 genes (thinnest: confidence 0.400; medium: confidence 0.700; thickest: confidence 0.900). Nodes with no interaction with other nodes were deleted. The interaction score was set at > 0.400 and KEGG pathway enrichment significance at P > 0.05 (FDR Benjamini-Hochberg)