Table 2.
Results of biodistribution of experimental formulations
| Organ/Tissues | Biodistribution of 99mTc-labeled experimental nanoliposomes in HCC induced rat model | |||||
|---|---|---|---|---|---|---|
| 99mTc-NLCs | 99mTc-PEG-NLCs | 99mTc-Apt-NLCs | ||||
| 4 h | 8 h | 4 h | 8 h | 4 h | 8 h | |
| Heart | 0.587 ± 0.043 | 0.347 ± 0.065 | 0.489 ± 0.047 | 0.309 ± 0.028 | 0.199 ± 0.026 | 0.155 ± 0.007 |
| Blood | 2.538 ± 0.067 | 1.484 ± 0.091 | 5.8973 ± 0.53 | 2.369 ± 0.366 | 4.392 ± 0.201 | 2.523 ± 0.115 |
| Liver | 37.234 ± 0.33 | 18.899 ± 1.25 | 47.686 ± 1.92# | 33.078 ± 1.06 | 60.69 ± 1.63* | 49.51 ± 0.478^ |
| Lung | 3.778 ± 0.209 | 2.554 ± 0.411 | 2.502 ± 0.295 | 2.678 ± 0.135 | 1.667 ± 0.349 | 2.319 ± 0.260 |
| Spleen | 0.627 ± 0.033 | 0.545 ± 0.036 | 0.833 ± 0.047 | 0.633 ± 0.106 | 0.724 ± 0.052 | 0.446 ± 0.042 |
| Muscle | 0.163 ± 0.013 | 0.142 ± 0.013 | 0.1893 ± 0.01 | 0.172 ± 0.022 | 0.118 ± 0.024 | 0.156 ± 0.011 |
| Intestine | 13.902 ± 0.29 | 8.988 ± 0.932 | 17.974 ± 0.61 | 14.27 ± 0.249 | 5.828 ± 0.074 | 3.651 ± 0.048 |
| Stomach | 0.487 ± 0.018 | 0.342 ± 0.028 | 0.653 ± 0.039 | 0.355 ± 0.012 | 0.387 ± 0.016 | 0.308 ± 0.032 |
| Kidney | 10.033 ± 0.71 | 4.461 ± 0.465 | 4.475 ± 0.276 | 3.254 ± 0.127 | 3.631 ± 0.406 | 2.591 ± 0.268 |
| Urine | 15.616 ± 0.14 | 14.706 ± 0.24 | 10.702 ± 0.82 | 9.755 ± 0.769 | 6.929 ± 0.851 | 5.654 ± 0.650 |
Data are expressed in % mean of injected dose (ID) per gram of organ/tissue ± SD (n = 3)
(#) Indicated significant (p < 0.05) amount of drug accumulation in liver in PEG-NLCs treated Gr over NLCs, while (*) indicated significant (p < 0.05) amount of drug accumulation in liver in Apt-PEG-NLCs treated Gr over PEG-NLCs Gr. at 4 h. (^) indicated significant (p < 0.05) amount of drug accumulation in liver in Apt-PEG-NLCs treated Gr over PEG-NLCs at 8 h