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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Hum Pathol. 2022 Dec 9;131:9–16. doi: 10.1016/j.humpath.2022.12.001

Figure 2: Trimethylation of H3K36 and aberrant expression of Beta-catenin.

Figure 2:

Figure 2A shows a loss of H3K36 trimethylation. This was found in 2 individuals with multiple SETD2 mutations. Figure 2B shows retained H3K36 trimethylation. All individuals with single mutations retained H3K36 trimethylation and one individual with multiple mutations. This may suggest that multiple SETD2 mutations are required for full loss of trimethylation of H3K36. Figure 2C shows aberrant cytoplasmic/nuclear beta-catenin expression in SETD2-mutated CRC with the loss of H3K36 trimethylation. Figure 2D shows dominant membranous beta-catenin expression.