Table 3 –

Mutations Co-Occurring with SETD2

Gene	N	%	Gene	N	%	Gene	N	%
TP53	14	58.3%	PIK3R1	3	12.5%	CTNNB1	1	4.2%
KRAS	12	50.0%	RB1	3	12.5%	ERBB2	1	4.2%
ATM	9	37.5%	RET	3	12.5%	ESR1	1	4.2%
BRCA2	8	33.3%	SMAD4	3	12.5%	EZH2	1	4.2%
ARID1A	8	33.3%	SMARCB1	3	12.5%	FANCA	1	4.2%
ATR	6	25.0%	TSC1	3	12.5%	FANCD2	1	4.2%
BRCA1	5	20.8%	TSC2	3	12.5%	FGF19	1	4.2%
CREBBP	5	20.8%	AR	2	8.3%	FGF3	1	4.2%
POLE	5	20.8%	BAP1	2	8.3%	FGFR2	1	4.2%
SMARCA4	5	20.8%	DDR2	2	8.3%	FLT3	1	4.2%
CDK12	4	16.7%	EGFR	2	8.3%	JAK1	1	4.2%
CDKN2B	4	16.7%	FANCI	2	8.3%	JAK3	1	4.2%
FBXW7	4	16.7%	MLH1	2	8.3%	KNSTRN	1	4.2%
MSH6	4	16.7%	MRE11A	2	8.3%	MAP2K1	1	4.2%
NF1	4	16.7%	MTOR	2	8.3%	MAP2K4	1	4.2%
NOTCH1	4	16.7%	NBN	2	8.3%	MDM2	1	4.2%
PMS2	4	16.7%	NTRK1	2	8.3%	MRE11A	1	4.2%
PTEN	4	16.7%	NTRK3	2	8.3%	MSH2	1	4.2%
RAD50	4	16.7%	PDGFRA	2	8.3%	MYC	1	4.2%
RNF43	4	16.7%	PIK3CB	2	8.3%	MYCL	1	4.2%
SLX4	4	16.7%	PTCH1	2	8.3%	MYCN	1	4.2%
ATRX	3	12.5%	ROS1	2	8.3%	NF2	1	4.2%
BRAF	3	12.5%	STK11	2	8.3%	PPARG	1	4.2%
ERBB3	3	12.5%	AKT2	1	4.2%	PPP2R1A	1	4.2%
KIT	3	12.5%	AKT3	1	4.2%	RAD51	1	4.2%
NOTCH2	3	12.5%	AXL	1	4.2%	RAD51B	1	4.2%
NOTCH3	3	12.5%	CCND3	1	4.2%	RAD51C	1	4.2%
PALB2	3	12.5%	CDK6	1	4.2%	RAD51D	1	4.2%
PDGFRB	3	12.5%	CHEK1	1	4.2%	RHEB	1	4.2%
PIK3CA	3	12.5%	CSF1R	1	4.2%