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. 2023 Jan 21;17:155–166. doi: 10.2147/DDDT.S379964

Table 3.

Hepatitis Delta Cure Modalities

Spontaneous Treatment-Guided
1. Isolated HDV-RNA clearance, with persistence of HBsAg+

  • Natural history

  • Peginterferon

  • Bulevirtide

  • Lonafarnib
2. HDV-RNA loss along with HBsAg seroreversion or seroconversion (functional hepatitis B cure)

  • Cross-immunity following distinct hepatic insults

  • Immune reconstitution syndromes (HIV on HAART, removal of immunosuppressants, etc.)

  • Peginterferon-⍺

  • HBV gene therapies (bepirovirsen, etc.)