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. 2022 Nov 27;10(3):2205191. doi: 10.1002/advs.202205191

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© 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Hybrid system for concurrent magnetic resonance optoacoustic tomography (MROT) imaging of murine brain activation. a) Illustration showing the imaging performance comparison between fMRI and OAT and the high complementary value of their combination for functional neuroimaging studies. b) Schematics of the hybrid MROT system featuring the 9.4T MRI bore inserted with a customized MRI‐compatible spherical matric array transducer for volumetric data acquisition, a fiber bundle for pulsed light delivery, animal fixation parts, and radiofrequency (RF) coils. c) Electrical stimulation paradigm applied to the left forepaw of a mouse. Stimulation cycle parameters: 0.5 ms pulse duration, 0.5 mA current, 4 Hz pulse repetition frequency, 20 s duration. One stimulation sequence consists of nine stimulation cycles repeated every 100 s. d) Volumetric OAT image of the mouse brain (HbO component is shown). e) The corresponding magnetic resonance angiography (MRA) image acquired with the fast low angle shot (FLASH) sequence. f) Axial and sagittal views of the coregistered OAT and MRA images.