. Author manuscript; available in PMC: 2023 Jan 25.

Published in final edited form as: Circ Genom Precis Med. 2019 Oct 22;12(11):e002723. doi: 10.1161/CIRCGEN.119.002723

Table 1.

Study Characteristics

Study	Country	Probands, n	Detection of Index Cases	Family Members, n	Contact and Collection	Testing
Bhatnagar et al¹⁴	United Kingdom	259	SBR	200	Letter advising an appointment with PCP	Biochemical
Umans-Eckenhausen et al¹⁶	The Netherlands	237	Diagnostic protocol followed by GT	5442	Nurse home visit	LDLR+Biochemical
Vergotine et al¹⁹	South Africa	379	GT	790	…	LDLR
Marks et al¹⁵	United Kingdom	227	SBR	165	Letter with choice of home visit or an SAC visit	Biochemical
Hadfield et al¹³	United Kingdom	733	SBR	769	Letter advising an appointment with GP or to attend SAC	Biochemical
Muir et al²⁴	New Zealand	76	GT	353	Letter advising to attend SAC	LDLR, APOB
Bell et al¹⁷	Australia	100	GT	366	Letter with telephone counseling and advice to attend SAC	LDLR, APOB, PCSK9
Jannes et al²⁰	Brazil	248	GT	394	Referral to SAC	LDLR, APOB, PCSK9
Latkovskis et al¹⁸	Latvia	140	DLCN score	68	…	Biochemical
Alver et al²³	Estonia	21	GT	64	Family member directed invite to SAC	LDLR, APOB, PCSK9

DLCN indicates Dutch Lipid Clinic Network; GP, general practitioner; GT, genetic testing; PCP, primary care provider; SAC, study-associated clinic; and SBR, Simon Broome Register.