Table 2.

Yield and NCIC: Contact Method, Degree of Relatedness, Sample Acquisition, and Testing Method

Study	Initial Contact Method	Relatives Tested	Site for Obtaining Sample	New Case Ascertainment	Yield, %	NCIC
Bhatnagar et al14	Direct	FDR	SAC or PCP	SBR criteria	60.50	0.47
Umans-Eckenhausen et al16	Direct	FDR, SDR, TDR	Nurse home visit	Diagnostic protocol followed by GT	37	8
Vergotine et al19	Unclear	FDR (close relatives)	Unclear	GT	42	0.89
Marks et al15	Indirect (response rate 35%)	FDR	Home visit or SAC	SBR criteria	30	0.22
Hadfield et al13	Direct and indirect	FDR	SAC or PCP	SBR criteria	30	0.7
Muir et al24	Direct (letter, laboratory form, consent)	FDR	Local laboratory	GT	45	2.09
Bell et al17	Indirect	FDR, SDR, TDR	SAC	GT	51.40	2
Jannes et al20	Direct	FDR*	SAC	GT	59.40	0.94
Latkovskis et al18	Indirect	FDR	SAC	DLCN score	60.30	0.29
Alver et al23	Indirect	FDR, SDR	SAC	GT	31	0.95

DLCN indicates Dutch Lipid Clinic Network; FDR, first-degree relative; FH, familial hypercholesterolemia; GT, genetic testing; NCIC, new cases per index case; PCP, primary care provider; SAC, study-associated clinic; SBR, Simon-Broom Registry; SDR, second-degree relative; and TDR, third-degree relative.

^*Cascade testing extended to SDRs of the proband upon detection of FH in FDRs.