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. Author manuscript; available in PMC: 2023 Jan 25.
Published in final edited form as: Mol Psychiatry. 2022 Jun 27;27(10):4023–4034. doi: 10.1038/s41380-022-01657-w

Figure 3. Distribution of CNS disorders by cell-specific enrichment.

Figure 3.

A) The percentage of CNS disorders (out of 112) that have significant (p-value <0.05) gene-set overlap with a specific cell type cluster. Cluster numbers are provided at the left, with non-neuronal clusters in blue (top), interneuron clusters in orange (middle), and PN cluster in purple (bottom). B) Percentage, of disease categories associated with PNs, interneurons (Int), and non-neurons (NN). Abridged disease categories (left labels) as provided by DisGeNET are used. The lighter-to-darker shades of blue represent the percentage of disease categories associated with each cell class. The number of diseases in each category is provided in parentheses. See Supplementary Figure 3 and Supplementary Table 7 for complete list of cell-disease association.