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Etiologies of ALF in the US within the US Acute Liver Failure Study Group.6 This prospective study included 308 patients admitted with ALF to 17 tertiary care centers in the US over a 41-month period. The most common etiology for ALF was acetaminophen, idiosyncratic drug reaction, and hepatitis B. The cause was indeterminate in 17% of cases. Malignant infiltration accounted for only 1% of all cases. Abbreviation: ALF indicates acute liver failure.
