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Effect of MIP-1α gene deletion on cerebral dissemination of C. neoformans in mice infected with C. neoformans 52D and C. neoformans 145A. Mice were infected intratracheally (C. neoformans 52D or C. neoformans 145A; 104 CFU) and analyzed 5 weeks postinfection (n = 5 to 19 per group). Data, pooled from separate matched experiments, are mean CFU per brain ± SE. Asterisk, P < 0.05, in comparison with 52D-infected group; dagger, P < 0.05, in comparison with WT mice.
