TABLE 1.
Demographic information and neuropsychological assessments
| ADNI cohort | Xuanwu cohort | |||||||
|---|---|---|---|---|---|---|---|---|
| Training data set | Application data set | Validation data set for SSIM | Validation data set for dissimilarity | |||||
| NC1 | AD | MCI | NC2 | NC3 | aMCI | naMCI | NC4 | |
| N | 412 | 292 | 309 | 300 | 105 | 35 | 35 | 35 |
| Age (years) | 72.47 ± 6.06 | 72.96 ± 6.92 | 73.40 ± 7.36 | 71.79 ± 5.46 | 65.61 ± 5.53*** | 66.97 ± 7.63 | 64.89 ± 7.51 | 65.46 ± 4.94 |
| Sex (F/M) | 228/184 | 150/142 | 137/172 && | 171/129 | 69/36 | 19/16 | 24/11 | 20/15 |
| Education (years) | 16.55 ± 2.52 | 15.35 ± 2.86 ### | 16.17 ± 2.71 | 16.43 ± 2.38 | 12.29 ± 3.12*** | 10.11 ± 3.76 §§ | 10.34 ± 3.31 †† | 12.00 ± 2.68 |
| MMSE | 29.10 ± 1.10 | 21.15 ± 4.49 ### | 26.13 ± 3.85 &&& | 28.83 ± 1.61 | / | / | / | / |
| CDR‐SB | 0.06 ± 0.21 | 5.44 ± 2.27 ### | 2.68 ± 2.36 &&& | 0.25 ± 1.07 | / | / | / | / |
| AVLT‐(long) D | / | / | / | / | 8.22 ± 2.56 | 2.46 ± 2.10 §§§ | 4.69 ± 2.30 ††† | 7.74 ± 2.07 |
| AVLT‐Recognition | / | / | / | / | 20.47 ± 4.61 | 7.53 ± 4.77 §§§ | 19.86 ± 3.01 | 22.83 ± 1.13 |
| MoCA‐B | / | / | / | / | 25.63 ± 3.04 | 18.6 ± 4.27 §§§ | 20.77 ± 3.99 ††† | 26.46 ± 2.03 |
| APOE ε4 | 124 (30.09%) | 134 (45.89%) ### | 126 (40.78%) && | 100 (33.33%) | 32 (30.48%%) | 15 (42.86%) | 13 (37.14%) | 7 (20.00%) |
| Aβ42 in CSF (Aβ+/Aβ−) | 24/53 | 73/14 | 45/21 | 24/12 | / | / | / | / |
| Follow‐up period for MCI (months) | / | / | 32.14 ± 29.54 | / | / | / | / | / |
| Converter rate of MCI | / | / | 41 (18.72%) | / | / | / | / | / |
Abbreviations: AD, Alzheimer's disease; aMCI, amnestic MCI; APOE, apolipoprotein E; AVLT, Auditory Verbal Learning Test; Aβ, amyloid β; CDR‐SB, Clinical Dementia Rating‐Sum of Boxes; CSF, cerebral spinal fluid; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; MoCA, Montreal Cognitive Assessment; naMCI, non‐aMCI; NC, normal control.
***
p < .001, comparison between NC1 and NC3.
###
p < .001, comparison between NC1 and AD.
&&
p < .01.
&&&
p < .001, comparison between NC1 and MCI.
§§
p < .01.
§§§
p < .01, comparison between NC3 and aMCI.
††
p < .01.
†††
p < .001, comparison between NC3 and naMCI.