TABLE 1.
Demographic characteristics of subjects
| Slovenia | |||||||
|---|---|---|---|---|---|---|---|
| Slovenia D | USA | Germany | |||||
| Slovenia A | Slovenia B | TP1 | TP2 | USA | Germany | ||
| bvFTD | N (M/F) | 20 (10/10) | 20 (8/12) | 6 (3/3) | 25 (16/9) | 44 (35/9) | |
| Age | 66.5 ± 10.8 | 71.0 ± 8.9 | 65.7 ± 6.6 | 68.4 ± 7.1 | 70.7 ± 10.5 | 63.1 ± 9.4 | |
| Disease duration | 2.8 ± 2.2 | 3.4 ± 2.7 | 2.2 ± 2.2 | 4.8 ± 3.0 | 3.0 ± 1.8 | 3.7 ± 3.1 | |
| MMSE | 19.3 ± 3.7 | 21.0 ± 5.0 | 27.8 ± 1.9 | 19.0 ± 1.0 | 25.2 ± 3.9 | 22.8 ± 4.8 | |
| CSF availability | 15/20 | 15/20 | ‐ | ‐ | ‐ | 15/44 | |
| CSF tau | 387 ± 123 | 420 ± 164 | ‐ | ‐ | ‐ | 361 ± 266 | |
| CSF p‐tau | 45 ± 9 | 56 ± 18 | ‐ | ‐ | ‐ | ‐ | |
| CSF amyloid‐beta | 1159 ± 252 | 1057 ± 317 | ‐ | ‐ | ‐ | 790 ± 379 | |
| HC | N (M/F) | 20 (8/12) | 20 (7/13) | 22 (12/10) | 15 (7/8) | ||
| Age | 66.7 ± 5.7 | 63.0 ± 9.1 | 69.7 ± 6.4 | 61.8 ± 9.1 | |||
| MMSE | 28.6 ± 1.2 | 29.1 ± 1.3 | ‐ | ‐ | |||
| Slovenia C | Germany | |||||
|---|---|---|---|---|---|---|
| AD | N (M/F) | 26 (14/12) | svPPA | 8 (2/6) | svPPA | 16 (10/6) |
| Age | 74.3 ± 9.8 | 65.1 ± 10.8 | 65.4 ± 4.4 | |||
| Disease duration | 3.9 ± 1.9 | 3.2 ± 1.8 | 3.8 ± 2.2 | |||
| MMSE | 19.0 ± 4.9 | 18.6 ± 5.7 | 22.3 ± 6.1 | |||
| CSF availability | 26/26 | 7/8 | ‐ | |||
| CSF tau | 712 ± 253 | 292 ± 116 | ‐ | |||
| CSF p‐tau | 94 ± 24 | 41 ± 15 | ‐ | |||
| CSF amyloid‐beta | 568 ± 94 | 1096 ± 82 | ‐ | |||
| sCJD | N (M/F) | 16 (7/9) | nfvPPA | 6 (5/6) | nfvPPA | 12 (6/6) |
| Age | 68.1 ± 10.7 | 68.6 ± 8.6 | 70.2 ± 8.9 | |||
| Disease duration | 0.4 ± 0.4 | 4.8 ± 3.3 | 3.5 ± 1.8 | |||
| MMSE | 15.0 ± 7.8 | 25.8 ± 1.3 | 20.9 ± 6.4 | |||
| CSF availability | 15/16 | 4/6 | ‐ | |||
| CSF tau | 2172 ± 347 | 222 ± 95 | ‐ | |||
| CSF p‐tau | 63 ± 23 | 42 ± 17 | ‐ | |||
| CSF amyloid‐beta | 1078 ± 419 | 1086 ± 281 | ‐ | |||
Note: Number of patients (N), gender (M, male; F, female), age at FDG‐PET, disease duration, Mini‐Mental State Examination (MMSE) scores and cerebrospinal fluid (CSF) biomarker results of all the studied cohorts are presented with mean and SD.
Abbreviations: AD, Alzheimer's disease; bvFTD, behavioral variant of frontotemporal dementia; HC, healthy controls; nfvPPA, nonfluent variant of primary progressive aphasia; sCJD, sporadic Creutzfeldt‐Jakob's disease; svPPA, semantic variant of primary progressive aphasia; TP1, time point 1; TP2, time point 2.