TABLE 3.
Protection against B. abortus 544 provided to BALB/c mice by vaccination with pCIBFR and pCIp39 compared to live strain B. abortus B19a or pCI alone
| Treatment group (n = 4) | Vaccine | Log10 brucellae in spleen (mean ± SD) at wk postchallenge
|
Log units of protection at wk
|
||
|---|---|---|---|---|---|
| 4 | 8 | 4 | 8 | ||
| 1 | —b | 4.95 ± 0.04 | 5.13 ± 0.23 | ||
| 2 | B19 | 2.95 ± 0.18 | 2.05 ± 0.28 | 2c | 3.08c |
| 3 | pCI | 4.96 ± 0.10 | 5.02 ± 0.10 | ||
| 4 | pCIBFR | 4.98 ± 0.61 | 5.0 ± 0.28 | ||
| 5 | pCIP39 | 4.80 ± 0.15 | 4.40 ± 0.15 | 0.15 | 0.73c |
a
Group 2 was vaccinated i.p. with 5 × 104 CFU of strain B19.
b
—, injected with PBS.
c
P < 0.05 (significant) compared with value for control mice.