Fig. 8. TRPV4 activity mediates loading-induced proteoglycan synthesis in the femoral condyles of dynamically cultured limbs.

sGAG deposition (histologically assessed using Toluidine blue stain) in the medial condyles (a, c, e, and g) and lateral condyles (b, d, f, and h) of femora subjected to static or dynamic culture, with TRPV4 antagonist RN-1734 (10 μM) or drug vehicle (DMSO) (n = 3 limbs per group). Boxes represent areas expanded for (a) to (h).