Fig. 9. TRPV4 mechanotransduction partially regulates loading-induced collagen deposition in the femoral condyles of dynamically cultured limbs.

Collagen deposition (histologically assessed using Picrosirius red) in the medial condyles (a, c, e, and g) and lateral condyles (b, d, f, and h) of femora subjected to static or dynamic culture, with TRPV4 antagonist RN-1734 (10 μM) or drug vehicle (DMSO) (n = 3 limbs per group). Boxes represent areas expanded for (a) to (h).