Table 1. Mutations identified in the direct targets of antibiotics.
| Antibiotic | Gene | Mutations identified |
|---|---|---|
| Rifampicin | rpoB | Leu452Pro, Val496Meth |
| Isoniazid | katG | Ser315Thr |
| Ethambutol | embB | Gly406Ser |
| Ofloxacin | gyrA | Ala90Val, Ser91Pro |
| Kanamycin | rrs | 7 independent mutations |
| Pyrazinamide | pncA | His71Arg |
| Ethionamide | ethA | Met95Arg, Pro160(frame-shift) |
| Streptomycin | gidB | Leu35 (frame-shift) |
| Cycloserine | ald | Thr427Pro |