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. 2023 Jan 25;12:e75860. doi: 10.7554/eLife.75860

Table 1. Mutations identified in the direct targets of antibiotics.

Antibiotic Gene Mutations identified
Rifampicin rpoB Leu452Pro, Val496Meth
Isoniazid katG Ser315Thr
Ethambutol embB Gly406Ser
Ofloxacin gyrA Ala90Val, Ser91Pro
Kanamycin rrs 7 independent mutations
Pyrazinamide pncA His71Arg
Ethionamide ethA Met95Arg, Pro160(frame-shift)
Streptomycin gidB Leu35 (frame-shift)
Cycloserine ald Thr427Pro