Figure 6.
TRIM72 might regulate the early stage of mitophagy through PI3K-AKT pathway. (a–c) Protein levels of PI3K, AKT, and their phosphorylated forms in tibial anterior muscles of blank, AAV-EV, and AAV-TRIM72-treated mdx mice, n = 4. (d, e) Western blot and quantification of ATG5 in tibial anterior muscles of WT and mdx mice, n = 6. (f, g) Western blot and quantification of ATG5 in tibial anterior muscles of three mdx groups, n = 4. Data were expressed as mean ± SEM. ∗p < 0.05.