Fig. 2.

Effects of the combinations of the four agents in human GBM cells. U-87 MG and A172 cells were treated with the indicated combinations of AZD5363, AZD8542, CCR and RV. After 72 h of treatments cell viability was determined by the MTT assay. Fresh medium and DMSO were used as negative control. (A) Left panel, shows survival (as percentage) of U-87 MG cells; the right panel shows the statistical analysis. (B) Left panel, shows survival (as percentage) of A172 cells; the right panel shows the statistical analysis. Bars are means ± SEM of three independent experiments. One-way ANOVA, followed by Games Howell, *p < 0.05.