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Proposed model to explain the action of the combined treatments. The combined treatments AZD5363+AZD8542+CCR or AZD8542+CCR+RV decrease the activation of AKT, reduce the expression of SMO, pP70S6k, pS6k, GLI1, p21 and p27, and activate the caspase-3 on U-87 MG and A172 cell lines.
