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. 2023 Jan 25;13:1392. doi: 10.1038/s41598-023-28347-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Integrated gradients pixel attributions. Pairs of macula and optic disc centred images of three different patient eyes and the obtained saliency maps (A) Severe NPDR, referable DME, DLS score 0.98. (B) Moderate NPDR, No DME, DLS score 0.58, (C) No DR, No DME, 0.04. The saliency maps highlight relevant lesions for the diagnosis (microaneurysms). In the absence of referable DR/DME, only the optic disc or general regions of the retina are highlighted.