Table 3.

Larger GM volume areas in MHT group (p < 0.05; threshold t-value 3.0 and cluster size more than 50 pixels).

Anatomical area	Abbr	t-value	Equivalent z-value	MNI coordinate			No. of voxels
				x	y	z
Two sample t-test
Middle frontal gyrus	MFG	3.87	3.54	− 23	34	27	2373
Hypothalamus	Hy	3.64	3.36	− 5	− 14	− 9	3060
Superior frontal gyrus	SFG	3.35	3.12	11	42	23	2167
Inferior frontal gyrus	IFG	3.28	3.06	− 40	24	21	1269
Postcentral gyrus	PoG	3.12	2.93	15	− 41	54	147
Angular gyrus	AnG	3.04	2.86	− 45	− 54	25	613
ANCOVA adjusting for age and TIV
Middle frontal gyrus	MFG	5.53	4.66	− 22	36	26	2966
Hypothalamus	Hy	4.89	4.24	− 4	− 14	− 9	292
Inferior temporal gyrus	ITG	4.48	3.96	52	− 28	− 30	797
Superior frontal gyrus	SFG	4.11	3.69	− 17	10	54	160
Parahippocampal gyrus	PHG	4.04	3.64	− 8	− 1	− 21	81
Inferior frontal gyrus	IFG	3.66	3.35	− 36	34	12	1179
Hippocampus	Hi	3.59	3.29	22	12	− 30	75
Cerebellar cortex	Cb	3.49	3.21	25	− 28	− 31	441
Postcentral gyrus	PoG	3.49	3.21	20	− 33	67	421
Precuneus	PCu	3.40	3.14	− 17	− 75	45	606
Angular gyrus	AnG	3.31	3.08	− 46	− 55	33	54
Supplementary motor area	MOs	3.04	2.86	− 9	15	52	108
Superior occipital gyrus	SOG	3.02	2.83	− 19	− 75	43	108
Precentral gyrus	PrG	3.00	2.81	30	− 24	54	130

MNI Montreal Neurological Institute, ANCOVA analysis of covariance, TIV total intracranial volume.

Moderate effect size of Cohen’s d (0.5) is threshold t-value 3.0.

t-value was calculated by two sample t-test and ANCOVA with adjusting covariates of age and TIV.