TABLE 1.
Day | Type of mice | Concn (pg/ml) of
|
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MCP-1 | IL-12 | IFN-γ | TNF-α | IL-10 | ||
0 | CCL3+/+ | <18 | <12 | 73 ± 5 | 97 ± 14 | 60 ± 6 |
CCL3−/− | <18 | <12 | 59 ± 5 | 76 ± 6 | 42 ± 12 | |
1 | CCL3+/+ | 22 ± 9 | 15 ± 10 | 82 ± 31 | 98 ± 30 | 38 ± 10 |
CCL3−/− | 49 ± 20 | 73 ± 54 | 34 ± 11 | 82 ± 23 | 19 ± 10 | |
2 | CCL3+/+ | 311 ± 131* | 192 ± 79 | 375 ± 211* | 219 ± 76* | 66 ± 23 |
CCL3−/− | 649 ± 159* | 281 ± 205* | 508 ± 320* | 785 ± 297* | 47 ± 19 | |
3 | CCL3+/+ | 201 ± 120* | 1,166 ± 838* | 784 ± 497* | 386 ± 239* | 34 ± 14 |
CCL3−/− | 405 ± 106* | 900 ± 663* | 1,193 ± 597* | 512 ± 278* | 25 ± 15 |
Cytokine level in BAL fluid of K. pneumoniae-infected CCL3+/+ and CCL3−/− mice (n = 5 to 7 per time point, from two independent experiments). *, P < 0.05, compared to day 0. Infected CCL3−/− animals did not differ significantly from infected CCL3+/+ animals at any time point.