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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Dec 29;43(2):234–252. doi: 10.1161/ATVBAHA.122.318135

Figure 7. Protective role of smooth muscle cell (SMC)-specific YAP in the aortic wall.

Figure 7.

A, Representative images of excised aortas showing more aortic damage in AngII-infused SMC-specific Yap-deficient mice (SMC-Yap−/− AngII; n=23) than in AngII-infused littermate control mice (SMC-Yap+/+ AngII; n=20). Boxes indicate rupture area. B, Median aortic diameters of SMC-Yap−/− AngII mice were enlarged in various aortic segments compared with those of SMC-Yap+/+ AngII mice. Asc, ascending; Desc, descending; SR, suprarenal; IR, infrarenal. C, The overall incidence of AAD was significantly higher in SMC-Yap−/− AngII mice than in SMC-Yap+/+ AngII mice. D-G, The incidence of AAD in different aortic segments was significantly lower in SMC-Yap−/− AngII mice than in SMC-Yap+/+ AngII mice. H, Wire myography analysis of ascending thoracic aortic rings showing that the contractile response to phenylephrine was significantly reduced in saline-infused SMC-Yap−/− mice (SMC-Yap−/− Saline, n=6) compared with saline-infused littermate control mice (SMC-Yap+/+ Saline, n=6). AngII infusion decreased contractile ability in both SMC-Yap−/− AngII mice (n=6) and SMC-Yap+/+ AngII mice (n=6). Multi-way analysis of variance with the Holm-Sidak test was used for pairwise comparisons in (H). Data are presented as mean ± standard deviation of the mean.