Figure 1.

Endothelium-Derived Factors and Their Receptors

The regulatory effect of endothelium-derived relaxing factors (EDRFs) and endothelium-derived contracting factors (EDCFs) on vascular tension depends on their specific receptor pathways. 5-HT = 5-hydroxytryptamine; 5HTR = 5-hydroxytryptamine receptor; 8-iso-PGF_2α = 8-iso-prostaglandin F_2α; A1, A_2A = type 1 purinergic receptors; ACE2 = angiotensin-converting enzyme 2; ADP = adenosine diphosphate; Ang = angiotensin; AT1R = angiotensin type 1 receptor; ATP = adenosine triphosphate; CRTH2 = prostaglandin D₂ receptor 2; DP = prostaglandin D₂ receptor; EET = epoxyeicosatrienoic acid; EP = prostaglandin E receptor; ET = endothelin; ET_A = endothelin receptor A; ET_B = endothelin receptor B; FP = prostaglandin F_2α receptor; GPCR = G protein–coupled receptor; IP = prostaglandin I₂ receptor; Mas = Mas receptor; P2X = type 2X purinergic receptor; P2Y = type 2Y purinergic receptor; PG = prostaglandin; sGC = soluble guanylate cyclase; TP = thromboxane A₂ receptor; TXA₂ = thromboxane A₂; UDP = uridine diphosphate; UTP = uridine triphosphate.