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ECL2 of GPR21 occupied orthosteric ligand‐binding pocket and mediated the activation of GPR21. (A) Amino acid residues of GPR21 ECL2. (B) Structure superimposition of ECL2 from Gs‐coupled GPR21, mini‐Gs‐coupled GPR52 and apo‐GPR52. ECL2 occupied similar orthosteric ligand‐binding pocket. (C) A cartoon representation of GPR21 ECL2. GPR21 ECL2 is composed of two different regions: immersed region (169–178) and the cap region (179–188).
