TABLE 1.
Cell counts and differentials in lavage fluid after Legionella challenge in AdmIFN-γ-treated animalsa
| Treatment of Legionella | Mean ± SEM
|
||
|---|---|---|---|
| Total no. of cells | No. of PMN | No. of mononuclear cells | |
| Untreated | (1.40 ± 0.24) × 105 | 425 ± 425 | (1.39 ± 0.23) × 105 |
| Day 1 | |||
| 0.9 NS | (3.01 ± 0.42) × 105 | (2.66 ± 0.38) × 105 | (0.35 ± 0.04) × 105 |
| AdCtl | (3.01 ± 0.74) × 105 | (2.68 ± 0.68) × 105 | (0.34 ± 0.07) × 105 |
| AdmIFN-γ | (2.85 ± 0.47) × 105 | (2.35 ± 0.44) × 105 | (0.50 ± 0.22) × 105 |
| Day 2 | |||
| 0.9 NS | (1.20 ± 0.19) × 106 | (1.08 ± 0.17) × 106 | (1.21 ± 0.24) × 105 |
| AdCtl | (7.78 ± 0.96) × 105 | (7.20 ± 0.89) × 105 | (5.77 ± 0.80) × 104 |
| AdmIFN-γ | (8.98 ± 0.25) × 105 | (8.05 ± 2.28) × 105 | (9.27 ± 2.72) × 104 |
a
Mice were challenged with 2 × 106 CFU of L. pneumophila concomitantly with AdmIFN-γ (5 × 108 PFU), AdCtl (5 × 108 PFU), or saline. On day 0, 1, and 2 after challenge, animals were sacrificed for BAL. (n = 5 animals per group). The experiment was performed once.