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. 2023 Jan 12;13:1020844. doi: 10.3389/fimmu.2022.1020844

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Copyright © 2023 Buhre, Pongracz, Künsting, Lixenfeld, Wang, Nouta, Lehrian, Schmelter, Lunding, Dühring, Kern, Petry, Martin, Föh, Steinhaus, von Kopylow, Sina, Graf, Rahmöller, Wuhrer and Ehlers

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Partial least squares-discriminant analysis (PLS-DA) of the study groups (A) PLS-DA of data collected from the naïve and pre-infected B+(B) vaccination cohorts between day (d) 100 and 170 upon first vaccination. Latent variable (LV) scores and loadings are shown. The area under the receiver operating characteristic curve (AUROC) for cross-validation is 0.8810 for both groups. (B) Color legend of the six vaccination groups. (C) PLS-DA of data collected from all naïve vaccination cohorts between day (d) 209 and 256 upon first vaccination. The AUROC values for cross-validation are B+B: 0.8304, M+M: 0.8449, A+A: 0.7416, A+B: 0.8773, and A+M: 0.9094.