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. 2023 Jan 12;12:1020566. doi: 10.3389/fonc.2022.1020566

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Copyright © 2023 Zhang, Zhang, Zheng, Lin, Wang, Zheng, Chen and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification and assessment of the CRG subtypes. (A) The consensus matrix, consensus cumulative distribution function (CDF), and delta area by cluster analysis based on CRGs. Two clusters (k=2) would be best. (B) Principal component analysis of two CRG clusters. (C) Kaplan-Meier survival curves of two CRG clusters (p < 0.001). (D) Heatmap of clinical features and CRGs expressions between subtypes. LDH, lactate dehydrogenases; ES, extranodal sites; ECOG, The Eastern Cooperative Oncology Group performance score; COO, cell of origin; IPI, International Prognostic Index.