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. 2023 Jan 12;13:1043481. doi: 10.3389/fphys.2022.1043481

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Copyright © 2023 Barron, Manna, McElwain, Musumeci, McCarthy, O’Keeffe and McCarthy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre-eclampsia serum alters mitochondrial function in differentiated SH-SY5Y Cells. (A) Oxygen consumption rate during 80-min Seahorse XF Mito Stress Test. Mean OCR values are normalized to protein content per well. (B) Graph representing individual parameters of respiration, calculated from the values plotted in I. Data are mean +SEM from N = 10 serum samples for each group with n = 1–5 wells per sample for I and J, or, expressed as percentage of the control. [*p < 0.05, **p < 0.01 vs. control. Mixed effects model and post-hoc Fisher’s least significant difference (LSD) test for (A), mann-whitney test for (B)].