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. 2023 Jan 12;13:1043481. doi: 10.3389/fphys.2022.1043481

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Copyright © 2023 Barron, Manna, McElwain, Musumeci, McCarthy, O’Keeffe and McCarthy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of findings and proposed mechanism. Elevated IL-6 is detected in the circulation of pregnant women with Pre-eclampsia, compared to healthy pregnant controls. When applied to RA- or RA/BDNF-differentiated SH-SY5Y cells, this serum induces increases in neurite growth and mitochondrial oxygen consumption. It is proposed that the elevated IL-6 in maternal serum in PE activates the IL-6 signaling pathway in these cells, terminating in the phosphorylation and consequent induction of the transcription factor STAT3 which alters the gene expression profile of the cell, contributing in part to this respiratory and neurite growth increase phenotype. Schematic created with Biorender.com.