TABLE 1.
Prevalence of connexin isoforms in various organs and their expression levels in diseases associated with the organs.
| Disease | Connexin expression | References | |
Heart
|
Atrial fibrillation | ↓ Cx43 | (237) |
| Atherosclerosis | ↑ Cx43 | (238) | |
| Chronic myocardial infarction | ↓ Cx43 | (239) | |
Eye
|
Retinoblastoma | ↑ Cx37 | (240) |
| Epithelioid melanoma | ↑ Cx43 | (240) | |
| Diabetic retinopathy | ↓ Cx43 | (241) | |
Inner ear
|
Noise induced hearing loss | ↓ Cx26 ↓ Cx30 |
(242) |
| Age related hearing loss | ↓ Cx26 ↓ Cx30 |
(243) | |
Bones
|
Oculodentodigital dysplasia (ODDD) | ↓ Cx43 | (244) |
| Rheumatoid arthritis | ↑ Cx43 | (245) | |
Skin
|
Acute eczema | ↓ Cx43 | (246) |
| Chronic eczema | ↑ Cx43 | (246) | |
| Melanoma | ↑ Cx26, Cx30.2 ↓ Cx43 |
(247) | |
Brain
|
Alzheimer’s disease | ↑ Cx43, Cx30 ↓ Cx47 |
(248) |