TABLE 2.

Summary table of the phosphorylation of Cx43-Serine-368 and expression level of PKC isozymes in various cardiac disorders.

Cardiac disease	Species/model	Cx43-serine-368 phosphorylation	PKC isozymes expression	References
Ischemia – reperfusion	Rat (Ischemia – reperfusion model)	↓ Ischemia ↑ Perfusion	↑ Perfusion PKC α and PKCε	(25, 175)
Myocarditis	Rat [experimental autoimmune myocarditis (EAM)]	↑	↑ PKC α	(184, 186)
Hypertrophy	Mice	–	↑ PKCβ	(189)
Hypertrophy	Neonatal cultured rat cardiomyocytes	–	↑ PKCα	(190)
Dilated cardiomyopathy	Human heart explants	–	↑ PKCα and PKCβ	(191)
Right ventricular hypertrophy	Rats	↓	–	(194)
Congestive heart failure	Dogs	↓	–	(205, 206)
Isoproterenol induced fibrillation	Rats	↑	↑PKCε	(225)
Myocardial infarction and heart failure	Hamsters	–	↑ PKC α, β, ε, ζ	(226)
Pressure overload induced heart failure	Guinea pigs	–	↑ PKCα and PKCε	(227)