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. 2022 Nov 23:10.1111/imm.13603. Online ahead of print. doi: 10.1111/imm.13603

FIGURE 1.

FIGURE 1

Number, frequency and FOXP3 MFI of blood and lung Tregs. PBMCs and BAL cells from patients with severe COVID‐19 were incubated for 12 h in the presence of BFA without stimulation. Number of Tregs per ml of blood (a) or BAL (b), frequencies of Tregs in CD4+ T cell population (c, d), and geometric means of FOXP3 expression by Tregs (e, f) were evaluated by flow cytometry. Survivors (open circles) n = 9 (D1), n = 4 or 6 (D3) and n = 6 (D7). Non‐survivors (grey triangles) n = 11 (D1), n = 8 (D3) and n = 8 (D7). The lines represent the geometric mean of each group. Differences between these two COVID‐19 groups were analysed by Mann–Whitney test and are indicated by asterisks (* for p < 0.05 and ** for p < 0.01) when statistically significant. BAL, broncho‐alveolar aspirate; PBMC, peripheral blood mononuclear cell.