TABLE 3.
i.n. immunization with P40G2Na protects naive or K. pneumoniae-primed mice from RSV-A infection
| Immunizing material | RSV-A titera in the following mice:
|
|||
|---|---|---|---|---|
| Naive
|
K. pneumoniae primed
|
|||
| Per g of lung | Per ml of nasal tract lavage fluid | Per g of lung | Per ml of nasal tract lavage fluid | |
| PBS i.n. | 4.55 ± 0.13 | 3.4 ± 0.48 | 4.11 ± 0.26 | 3.16 ± 0.19 |
| P40 i.n. | 4.2 ± 0.41b | 2.95 ± 0.48b | 4.4 ± 0.49b | 2.99 ± 0.43b |
| P40G2Na i.n. | 1.49 ± 0.1c | 2.28 ± 0.7d | 1.49 ± 0.1c | 0.99 ± 0.75c |
a
Log10 TCID50, reported as means and standard deviations.
b
Not significantly different from control value.
c
The P value for a comparison with the control was <0.001.
d
The P value for a comparison with the control was <0.01.