TABLE 2.
Summary of Voxel‐Wise Analyses of CBF
| Comparison | Direction | Size | t‐statistic | x | y | z | Description |
|---|---|---|---|---|---|---|---|
| COVID‐19 (n = 39) vs. Controls (n = 11) | COVID‐19 < Controls | 6012 | 5.05 | 20 | –4 | 8 | Pallidum, caudate, nucleus accumbens, putamen, thalamus, frontal medial cortex, subcallosal cortex, anterior cingulate gyrus, paracingulate gyrus |
| 577 | 5.21 | −8 | −54 | −18 | Lingual gyrus, occipital fusiform gyrus, temporal occipital fusiform cortex | ||
| Sensitivity analysis—partial volume correction | |||||||
| COVID‐19 (n = 39) vs. Controls (n = 11) with partial volume correction | COVID‐19 < Controls | 1725 | 4.42 | −10 | 8 | 10 | Occipital fusiform grus, temporal occipital fusiform cortex |
| 541 | 6.12 | −36 | −76 | −14 | Occipital fusiform gyrus, inferior lateral occipital cortex, lingual gyrus | ||
| 284 | 5.13 | −26 | −64 | −16 | Pallidum, caudate, nucleus accumbens, putamen, thalamus, frontal medial cortex, subcallosal cortex, orbitofrontal cortex, frontal medial Ccortex | ||
| Exploratory Analysis—Effects of Fatigue on CBF within the COVID‐19 group | |||||||
| COVID‐19 with fatigue (n = 11) vs. COVID‐19 without fatigue (n = 28) | COVID‐19 with fatigue > COVID‐19 without fatigue | 3558 | 6.16 | 32 | −60 | 48 | Superior lateral occipital crtex, angular gyrus, superior parietal lobule, supramarginal gyrus |
| 500 | 4.53 | 46 | −4 | 50 | Precentral gyrus, middle frontal gyrus | ||
| 385 | 4.44 | 0 | −30 | 22 | Posterior cingulate gyrus, caudate, thalamus | ||
| COVID‐19 with fatigue <COVID‐19 without fatigue | 363 | 5.02 | 22 | −90 | −18 | Lingual gyrus, occipital fusiform gyrus, intracalcarine cortex, precuneous cortex | |
The primary (top row) and secondary analyses (bottom rows) show results from between‐(sub)group comparisons of CBF, controlling for age and sex. Coordinates indicate location of peak t‐statistic.