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. 2022 Nov 10;95(1):e28266. doi: 10.1002/jmv.28266

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© 2022 Wiley Periodicals LLC.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Acid sphingomyelinase (ASM) inhibition suppresses SARS‐CoV‐2 S pseudovirion infection in vitro and in vivo. (A) Shown are pseudovirion infections in A549 cells treated with different kinds of inhibitors. Results are shown as the mean ± SD. ***p < 0.001. (B) Inhibition of viral infection by ASM silencing. Results are shown as the mean ± SD. ***p < 0.001. (C) Diagram depicting the in vivo SARS‐CoV‐2 S pseudovirion infection assay. (D) Messenger RNA expressions of enhanced green fluorescent protein in the tumour samples. Results are shown as the mean ± SD. ***p < 0.001. SD, standard deviation.