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. 2023 Jan 1:10.1111/acer.15000. Online ahead of print. doi: 10.1111/acer.15000

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© 2022 Research Society on Alcoholism.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Effect of chronic intermittent EtOH (CIE) exposure on the TPH2 and ACE2 immunoreactivity in raphe magnus (RMG). Representative confocal images showing (A, D) TPH2 (green) (B, E) ACE2 (red) (C, F) TPH2‐ACE2 (yellow) positive neurons in RMG of air and CIE mice. Scale bar = 50 μm. Graph showing (G) % immunoreactive area for ACE2 and TPH2, (H) % immunoreactive area for TPH2‐ACE2 positive neurons, (I) Pearson correlation coefficient for TPH2‐ACE2 colocalization (J) Mander's overlap coefficient for TPH2‐ACE2 colocalization in RMG. Values (n = 4 to 5/group) are represented as mean (±SEM) and the data were analyzed by unpaired Student's t‐test with Welch's correction (*p < 0.05, **p < 0.01 vs. air control).