TABLE 2.
Significantly abundant miRNAs in the blood of TGA patients compared to controls as determined by microarray.
| microRNA | Fold change | Adjusted P-value |
Regulation |
| (A) TGA patients (n = 31) vs. controls (n = 15) | |||
| miR-494-3p | 0.47 | 0.0240 | Lower |
| miR-150-5p | 0.50 | 0.0003 | Lower |
| miR-125a-5p | 0.50 | 0.0099 | Lower |
| miR-342-3p | 0.51 | 0.0001 | Lower |
| miR-99b-5p | 0.52 | 0.0049 | Lower |
| miR-145-5p | 0.59 | 0.0120 | Lower |
| miR-199a-5p | 0.61 | 0.0384 | Lower |
| miR-1246 | 0.61 | 0.0120 | Lower |
| miR-93-3p | 0.62 | 0.0003 | Lower |
| miR-193b-3p | 0.62 | 0.0025 | Lower |
| miR-361-5p | 0.62 | 0.0003 | Lower |
| miR-15b-3p | 0.63 | 0.0153 | Lower |
| miR-6794-3p | 0.63 | 0.0135 | Lower |
| miR-532-3p | 0.63 | 0.0025 | Lower |
| miR-23a-3p | 0.63 | 0.0161 | Lower |
| miR-6125 | 0.63 | 0.0192 | Lower |
| miR-4732-5p | 0.63 | 0.0207 | Lower |
| miR-942-5p | 0.63 | 0.0172 | Lower |
| miR-128-3p | 0.63 | 0.0006 | Lower |
| miR-23b-3p | 0.65 | 0.0129 | Lower |
| miR-629-3p | 0.66 | 0.0117 | Lower |
| miR-1275 | 0.66 | 0.0492 | Lower |
| miR-139-5p | 0.66 | 0.0192 | Lower |
| miR-454-5p | 0.67 | 0.0157 | Lower |
| miR-6819-3p | 1.59 | 0.0011 | Higher |
| miR-103a-3p | 1.59 | 0.0492 | Higher |
| miR-29b-3p | 1.67 | 0.0240 | Higher |
| miR-590-5p | 1.70 | 0.0208 | Higher |
| miR-140-5p | 1.71 | 0.0194 | Higher |
| miR-106b-5p | 1.74 | 0.0038 | Higher |
| miR-29c-3p | 1.74 | 0.0135 | Higher |
| miR-301a-3p | 1.77 | 0.0135 | Higher |
| miR-148a-3p | 1.81 | 0.0210 | Higher |
| miR-17-3p | 2.29 | 0.0044 | Higher |
| miR-18b-5p | 2.30 | 0.0012 | Higher |
| miR-18a-5p | 2.58 | 0.0051 | Higher |
| miR-101-3p | 2.64 | 0.0135 | Higher |
| miR-144-5p | 2.81 | 0.0455 | Higher |
| miR-144-3p | 3.08 | 0.0429 | Higher |
| (B) TGA-LV patients (n = 15) vs. TGA-RV | |||
| miR-4665-3p | 0.58 | 0.0223 | Lower |
| miR-4505 | 0.59 | 0.0110 | Lower |
| miR-4299 | 0.63 | 0.0123 | Lower |
| miR-1306-5p | 1.50 | 0.0240 | Higher |
| miR-21-3p | 1.53 | 0.0346 | Higher |
| miR-6803-3p | 1.54 | 0.0224 | Higher |
| miR-22-5p | 1.55 | 0.0110 | Higher |
| miR-378a-3p | 1.56 | 0.0224 | Higher |
| miR-574-3p | 1.57 | 0.0240 | Higher |
| miR-296-5p | 1.57 | 0.0257 | Higher |
| miR-1255b-5p | 1.59 | 0.0240 | Higher |
| miR-505-3p | 1.59 | 0.0284 | Higher |
| miR-501-3p | 1.60 | 0.0427 | Higher |
| miR-5690 | 1.60 | 0.0308 | Higher |
| miR-3200-3p | 1.61 | 0.0110 | Higher |
| miR-193b-3p | 1.62 | 0.0110 | Higher |
| miR-93-3p | 1.62 | 0.0206 | Higher |
| miR-212-3p | 1.63 | 0.0350 | Higher |
| miR-4449 | 1.65 | 0.0110 | Higher |
| miR-664a-5p | 1.66 | 0.0240 | Higher |
| miR-211-3p | 1.66 | 0.0341 | Higher |
| miR-378g | 1.66 | 0.0259 | Higher |
| miR-6073 | 1.68 | 0.0384 | Higher |
| miR-629-3p | 1.70 | 0.0110 | Higher |
| miR-15b-3p | 1.71 | 0.0308 | Higher |
| miR-3200-5p | 1.71 | 0.0492 | Higher |
| miR-500b-5p | 1.72 | 0.0164 | Higher |
| miR-6794-3p | 1.73 | 0.0110 | Higher |
| miR-664a-3p | 1.74 | 0.0350 | Higher |
| miR-181b-5p | 1.75 | 0.0240 | Higher |
| miR-1260b | 1.77 | 0.0405 | Higher |
| miR-339-3p | 1.79 | 0.0110 | Higher |
| miR-3907 | 1.79 | 0.0110 | Higher |
| miR-99a-5p | 1.80 | 0.0110 | Higher |
| miR-4732-5p | 1.80 | 0.0308 | Higher |
| miR-454-5p | 1.84 | 0.0017 | Higher |
| miR-99b-5p | 1.85 | 0.0259 | Higher |
| miR-340-5p | 1.85 | 0.0259 | Higher |
| miR-500a-5p | 1.86 | 0.0308 | Higher |
| miR-1246 | 1.87 | 0.0110 | Higher |
| miR-339-5p | 1.88 | 0.0240 | Higher |
| miR-378a-5p | 1.88 | 0.0484 | Higher |
| miR-186-5p | 1.89 | 0.0341 | Higher |
| miR-378d | 1.93 | 0.0223 | Higher |
| miR-942-5p | 1.99 | 0.0110 | Higher |
| miR-6085 | 2.12 | 0.0127 | Higher |
| miR-30a-5p | 2.20 | 0.0492 | Higher |
| miR-6826-5p | 2.30 | 0.0223 | Higher |
| miR-145-5p | 2.31 | 0.0110 | Higher |
| miR-125b-5p | 2.44 | 0.0240 | Higher |
| miR-3135b | 2.79 | 0.0061 | Higher |
| (C) TGA-RV patients (n = 16) vs. controls (n = 15) | |||
| miR-99b-5p | 0.39 | 0.0012 | Lower |
| miR-145-5p | 0.39 | 0.0013 | Lower |
| miR-125a-5p | 0.41 | 0.0012 | Lower |
| miR-125b-5p | 0.41 | 0.0079 | Lower |
| miR-150-5p | 0.43 | 0.0010 | Lower |
| miR-342-3p | 0.43 | 0.0004 | Lower |
| miR-494-3p | 0.44 | 0.0156 | Lower |
| miR-3135b | 0.44 | 0.0065 | Lower |
| miR-484 | 0.45 | 0.0156 | Lower |
| miR-1246 | 0.45 | 0.0007 | Lower |
| miR-4428 | 0.45 | 0.0275 | Lower |
| miR-942-5p | 0.45 | 0.0023 | Lower |
| miR-8485 | 0.47 | 0.0160 | Lower |
| miR-4732-5p | 0.48 | 0.0079 | Lower |
| miR-6794-3p | 0.48 | 0.0006 | Lower |
| miR-15b-3p | 0.48 | 0.0013 | Lower |
| miR-409-3p | 0.48 | 0.0329 | Lower |
| miR-326 | 0.49 | 0.0145 | Lower |
| miR-378a-5p | 0.49 | 0.0156 | Lower |
| miR-93-3p | 0.49 | 0.0004 | Lower |
| miR-339-5p | 0.49 | 0.0079 | Lower |
| miR-193b-3p | 0.49 | 0.0004 | Lower |
| miR-454-5p | 0.50 | 0.0003 | Lower |
| miR-199a-5p | 0.50 | 0.0087 | Lower |
| miR-629-3p | 0.51 | 0.0013 | Lower |
| miR-186-5p | 0.52 | 0.0423 | Lower |
| miR-574-3p | 0.54 | 0.0004 | Lower |
| miR-532-3p | 0.54 | 0.0019 | Lower |
| miR-5189-3p | 0.54 | 0.0393 | Lower |
| miR-6789-5p | 0.54 | 0.0431 | Lower |
| miR-361-5p | 0.54 | 0.0002 | Lower |
| miR-3200-5p | 0.54 | 0.0114 | Lower |
| miR-99a-5p | 0.55 | 0.0013 | Lower |
| miR-361-3p | 0.57 | 0.0164 | Lower |
| miR-191-5p | 0.57 | 0.0106 | Lower |
| miR-139-5p | 0.57 | 0.0079 | Lower |
| miR-505-3p | 0.57 | 0.0065 | Lower |
| miR-6125 | 0.57 | 0.0102 | Lower |
| miR-151a-3p | 0.57 | 0.0156 | Lower |
| miR-664a-3p | 0.57 | 0.0256 | Lower |
| miR-30c-5p | 0.57 | 0.0329 | Lower |
| miR-3200-3p | 0.58 | 0.0017 | Lower |
| miR-128-3p | 0.58 | 0.0006 | Lower |
| miR-30b-5p | 0.58 | 0.0300 | Lower |
| miR-5690 | 0.58 | 0.0046 | Lower |
| miR-4672 | 0.58 | 0.0195 | Lower |
| miR-423-3p | 0.58 | 0.0156 | Lower |
| miR-23a-3p | 0.58 | 0.0093 | Lower |
| miR-574-5p | 0.59 | 0.0300 | Lower |
| miR-4732-3p | 0.59 | 0.0329 | Lower |
| miR-2861 | 0.59 | 0.0232 | Lower |
| miR-92a-3p | 0.59 | 0.0065 | Lower |
| miR-7-1-3p | 0.60 | 0.0058 | Lower |
| miR-1275 | 0.61 | 0.0304 | Lower |
| miR-4449 | 0.61 | 0.0170 | Lower |
| miR-501-3p | 0.61 | 0.0279 | Lower |
| miR-5001-5p | 0.62 | 0.0221 | Lower |
| miR-7704 | 0.62 | 0.0303 | Lower |
| miR-10a-5p | 0.63 | 0.0080 | Lower |
| miR-4721 | 0.63 | 0.0410 | Lower |
| miR-1271-5p | 0.63 | 0.0140 | Lower |
| miR-1268b | 0.63 | 0.0489 | Lower |
| miR-6803-3p | 0.63 | 0.0080 | Lower |
| miR-23b-3p | 0.63 | 0.0184 | Lower |
| miR-6513-3p | 0.63 | 0.0017 | Lower |
| miR-212-3p | 0.64 | 0.0233 | Lower |
| miR-654-3p | 0.64 | 0.0156 | Lower |
| miR-296-5p | 0.64 | 0.0284 | Lower |
| miR-3180-3p | 0.64 | 0.0327 | Lower |
| miR-222-3p | 0.64 | 0.0376 | Lower |
| miR-3605-3p | 0.65 | 0.0050 | Lower |
| miR-324-3p | 0.65 | 0.0036 | Lower |
| miR-130b-5p | 0.65 | 0.0079 | Lower |
| miR-1268a | 0.66 | 0.0326 | Lower |
| miR-423-5p | 0.66 | 0.0384 | Lower |
| miR-6511b-3p | 0.66 | 0.0238 | Lower |
| miR-29b-3p | 1.58 | 0.0384 | Higher |
| miR-4713-3p | 1.64 | 0.0384 | Higher |
| miR-4665-3p | 1.64 | 0.0164 | Higher |
| miR-4433a-5p | 1.66 | 0.0046 | Higher |
| miR-29c-3p | 1.70 | 0.0122 | Higher |
| miR-3198 | 1.70 | 0.0405 | Higher |
| miR-5581-5p | 1.72 | 0.0304 | Higher |
| miR-6131 | 1.72 | 0.0393 | Higher |
| miR-1305 | 1.74 | 0.0304 | Higher |
| miR-6740-5p | 1.75 | 0.0398 | Higher |
| miR-33b-3p | 1.77 | 0.0106 | Higher |
| miR-6819-3p | 1.86 | 0.0037 | Higher |
| miR-6717-5p | 1.88 | 0.0203 | Higher |
| miR-106b-5p | 1.90 | 0.0069 | Higher |
| miR-301a-3p | 1.97 | 0.0310 | Higher |
| miR-19a-3p | 2.03 | 0.0160 | Higher |
| miR-17-5p | 2.34 | 0.0491 | Higher |
| miR-18b-5p | 2.65 | 0.0079 | Higher |
| miR-17-3p | 2.67 | 0.0126 | Higher |
| miR-96-5p | 2.78 | 0.0471 | Higher |
| miR-20a-5p | 2.86 | 0.0310 | Higher |
| miR-18a-5p | 3.22 | 0.0144 | Higher |
| miR-101-3p | 3.59 | 0.0164 | Higher |
| miR-144-5p | 5.01 | 0.0097 | Higher |
| miR-144-3p | 6.40 | 0.0156 | Higher |
An unpaired two-tailed t-test was used to calculate the P-value. TGA-RV, transposition of the great arteries with a systemic right ventricle; TGA-LV, transposition of the great arteries with a systemic left ventricle; AUC, area under the curve.