TABLE 3.

Significantly abundant mRNAs in the blood of TGA patients compared to controls as determined by microarray.

(A) TGA patients (n = 32) vs. controls (n = 16)
mRNA	Fold change	Adjusted P-value	Regulation	mRNA	Fold change	Adjusted P-value	Regulation
TMOD1	0.47	0.0321	Lower	LRRN3	2.47	0.0394	Higher
PRSS33	0.52	0.0270	Lower	TRABD2A	1.84	0.0448	Higher
SFRP2	0.55	0.0493	Lower	CD8B2	1.84	0.0206	Higher
RGS1	0.55	0.0485	Lower	PLEKHB1	1.71	0.0210	Higher
SRXN1	0.55	0.0181	Lower	IQCN	1.71	0.0340	Higher
RHCE	0.56	0.0444	Lower	CD248	1.70	0.0306	Higher
TFDP1	0.59	0.0298	Lower	IL7R	1.69	0.0449	Higher
DNAJC6	0.59	0.0476	Lower	TMIGD2	1.66	0.0274	Higher
HRH4	0.59	0.0433	Lower	C1QTNF6	1.62	0.0480	Higher
PTPRF	0.60	0.0286	Lower	NRCAM	1.61	0.0357	Higher
NRP1	0.60	0.0466	Lower	ASIC1	1.56	0.0449	Higher
RIPOR3	0.60	0.0204	Lower	NPM3	1.56	0.0382	Higher
DACH1	0.61	0.0444	Lower	GSDMB	1.56	0.0425	Higher
STOM	0.61	0.0347	Lower	NOSIP	1.54	0.0362	Higher
TMC5	0.62	0.0350	Lower	PTPRCAP	1.54	0.0237	Higher
MPP1	0.64	0.0440	Lower	PBX4	1.52	0.0203	Higher
OXER1	0.64	0.0300	Lower	OFD1	1.50	0.0209	Higher
CLEC5A	0.65	0.0218	Lower	SCML4	1.50	0.0278	Higher
(B) TGA-RV patients (n = 16) vs. controls (n = 16)
mRNA	Fold change	Adjusted P-value	Regulation	mRNA	Fold change	Adjusted P-value	Regulation
YOD1	0.27	0.0321	Lower	EPHX2	2.21	0.0336	Higher
PDGFC	0.36	0.0373	Lower	CD8B2	2.15	0.0146	Higher
TRIM58	0.38	0.0340	Lower	RHPN1	2.10	0.0157	Higher
TENT5C	0.40	0.0343	Lower	KLK1	2.04	0.0349	Higher
XK	0.40	0.0456	Lower	PLEKHB1	1.95	0.0326	Higher
TMOD1	0.40	0.0256	Lower	TCF7	1.95	0.0419	Higher
JAZF1	0.40	0.0455	Lower	CD248	1.93	0.0135	Higher
RNF11	0.40	0.0346	Lower	FHIT	1.91	0.0420	Higher
SNCA	0.40	0.0370	Lower	CD8B	1.90	0.0457	Higher
FOXO3	0.41	0.0275	Lower	CCR10	1.81	0.0451	Higher
GCLC	0.41	0.0403	Lower	C12orf57	1.81	0.0411	Higher
KAT2B	0.42	0.0414	Lower	NPM3	1.78	0.0180	Higher
FURIN	0.43	0.0348	Lower	PCSK4	1.76	0.0114	Higher
TPM1	0.44	0.0330	Lower	C1QTNF6	1.75	0.0437	Higher
RHOBTB1	0.45	0.0460	Lower	IQCN	1.74	0.0365	Higher
SLC7A5	0.45	0.0450	Lower	ASIC1	1.74	0.0141	Higher
PIP5K1B	0.45	0.0368	Lower	FXYD2	1.73	0.0401	Higher
CTNNAL1	0.46	0.0345	Lower	TMIGD2	1.72	0.0370	Higher
RAP2A	0.46	0.0439	Lower	NRCAM	1.72	0.0317	Higher
CALD1	0.47	0.0451	Lower	HIST1H1D	1.71	0.0375	Higher
FNBP1L	0.47	0.0321	Lower	NOSIP	1.69	0.0326	Higher
ARHGAP6	0.48	0.0371	Lower	TLE2	1.66	0.0356	Higher
CREG1	0.49	0.0362	Lower	AMIGO1	1.66	0.0459	Higher
TBCEL	0.50	0.0445	Lower	SYNE4	1.66	0.0349	Higher
GCNT1	0.50	0.0320	Lower	PTPRCAP	1.64	0.0340	Higher
GSPT1	0.50	0.0401	Lower	SELENOM	1.64	0.0458	Higher
RIOK3	0.50	0.0445	Lower	SOX8	1.64	0.0457	Higher
PDCD10	0.50	0.0374	Lower	KLHL34	1.63	0.0209	Higher
ABCB10	0.50	0.0458	Lower	NPY4R	1.62	0.0404	Higher
TTC7B	0.51	0.0326	Lower	GSDMB	1.61	0.0444	Higher
DNAJC6	0.51	0.0340	Lower	LIG1	1.61	0.0110	Higher
ADIPOR1	0.51	0.0346	Lower	FAM174B	1.60	0.0350	Higher
RGS1	0.52	0.0449	Lower	SLC27A5	1.60	0.0430	Higher
NRP1	0.52	0.0358	Lower	RPL36	1.60	0.0255	Higher
TMC5	0.52	0.0167	Lower	HPDL	1.58	0.0460	Higher
BNIP3L	0.52	0.0322	Lower	SCML4	1.58	0.0255	Higher
RIPOR3	0.52	0.0118	Lower	CD7	1.57	0.0353	Higher
STOM	0.53	0.0341	Lower	COL6A1	1.57	0.0373	Higher
DNM3	0.53	0.0349	Lower	VILL	1.56	0.0456	Higher
NIPSNAP3A	0.53	0.0432	Lower	MYL6B	1.56	0.0454	Higher
F13A1	0.53	0.0422	Lower	MTFP1	1.56	0.0330	Higher
FAM104A	0.53	0.0313	Lower	C19orf48	1.55	0.0369	Higher
TFDP1	0.53	0.0372	Lower	GPC2	1.54	0.0311	Higher
XYLT1	0.53	0.0451	Lower	SFI1	1.54	0.0328	Higher
CLIC2	0.53	0.0117	Lower	MRNIP	1.54	0.0124	Higher
RHCE	0.53	0.0420	Lower	CD27	1.54	0.0406	Higher
MKRN1	0.53	0.0373	Lower	MST1R	1.53	0.0404	Higher
TUBB1	0.54	0.0463	Lower	ZFP90	1.53	0.0441	Higher
PTPRF	0.54	0.0192	Lower	TEDC1	1.53	0.0341	Higher
SRXN1	0.54	0.0158	Lower	ATP5IF1	1.53	0.0314	Higher
DAB2	0.54	0.0461	Lower	SPEG	1.52	0.0440	Higher
SFRP2	0.54	0.0453	Lower	ZNF692	1.52	0.0120	Higher
SLC25A37	0.54	0.0433	Lower	STMN3	1.52	0.0452	Higher
PIP4K2A	0.55	0.0179	Lower	ZNF444	1.52	0.0115	Higher
GP6	0.56	0.0413	Lower	TMEM160	1.51	0.0358	Higher
GUCY1B1	0.56	0.0473	Lower	TESPA1	1.51	0.0314	Higher
HRH4	0.56	0.0422	Lower	ADAMTS13	1.51	0.0156	Higher
EPB41	0.57	0.0372	Lower	PBX4	1.51	0.0458	Higher
VEGFC	0.57	0.0438	Lower	ATAD3B	1.50	0.0431	Higher
HEXIM1	0.57	0.0385	Lower
HNMT	0.57	0.0444	Lower
DACH1	0.58	0.0357	Lower
GAPT	0.58	0.0363	Lower
RPIA	0.58	0.0412	Lower
MPP1	0.58	0.0333	Lower
COPS2	0.58	0.0458	Lower
CHMP4B	0.59	0.0323	Lower
P2RY12	0.59	0.0460	Lower
FAM117A	0.59	0.0458	Lower
BMP6	0.59	0.0370	Lower
DCAF6	0.59	0.0242	Lower
MPL	0.60	0.0446	Lower
CA8	0.60	0.0410	Lower
GOLM1	0.60	0.0473	Lower
ACPP	0.60	0.0317	Lower
STON1	0.60	0.0458	Lower
RNF10	0.60	0.0373	Lower
BHLHE40	0.61	0.0370	Lower
SNX3	0.61	0.0411	Lower
SPTA1	0.61	0.0348	Lower
WNK1	0.61	0.0421	Lower
CLEC5A	0.61	0.0403	Lower
RAB27B	0.61	0.0442	Lower
KLRB1	0.61	0.0459	Lower
ODC1	0.62	0.0345	Lower
OPTN	0.62	0.0453	Lower
ATP6V0C	0.62	0.0358	Lower
TAL1	0.62	0.0460	Lower
DHX29	0.62	0.0460	Lower
ZNF469	0.62	0.0345	Lower
UBE2E3	0.63	0.0459	Lower
VCL	0.63	0.0359	Lower
HK1	0.63	0.0366	Lower
KIF1B	0.63	0.0482	Lower
LRP12	0.63	0.0440	Lower
PCDH9	0.64	0.0464	Lower
TFPI	0.64	0.0459	Lower
LTBP1	0.64	0.0342	Lower
VLDLR	0.64	0.0451	Lower
BMP2K	0.65	0.0375	Lower
RNF14	0.65	0.0418	Lower
SELENOK	0.65	0.0334	Lower
C2orf76	0.66	0.0310	Lower
SLC6A4	0.66	0.0456	Lower
CTNNA1	0.66	0.0461	Lower

An unpaired two-tailed t-test was used to calculate the P-value. TGA-RV, transposition of the great arteries with a systemic right ventricle.