TABLE 2.
Genotypic and allelic frequencies of IL6‐597(G > A) and IL6‐174(G > C) gene polymorphisms in mild (n = 145) and COVID‐19 severe cases (n = 97)
|
Genotypes/alleles 145 (60.0) |
97 (40.0) |
Mild (n, %) Unadjusted OR (95% CI) |
p Value |
Severe (n, %) Adjusted b OR (95% CI) |
p Value | |
|---|---|---|---|---|---|---|
| IL6 −174 G > C | ||||||
| GG | 120 (82.8) | 66 (68) | 1.0 (Ref.) | 1.0 (Ref.) | ||
| GC | 25 (17.2) | 31 (32.0) | 2.26 (1.22–4.13) | .009 | 3.86 (1.81–8.24) | <.001 |
| CC | — | — | — | — | — | |
| G a | 265 (91.3) | 163 (84.0) | 1.0 (Ref.) | |||
| C a | 25 (8.7) | 31 (16.0) | 2.02 (1.149–3.536) | .014 | ||
| HWE | 0.524 | 0.173 | ||||
| IL6 −597 G > A | ||||||
| AA | 84 (57.9) | 61 (62.9) | 1.0 (Ref.) | 1.0 (Ref.) | ||
| AG | 59 (40.7) | 34 (35.1) | 0.79 (0.465–1.356) | .397 | 0.86 (0.47–1.57) | .626 |
| GG | 2 (1.4) | 2 (2.0) | 1.37 (0.189–10.04) | .752 | 1.17 (0.11–11.99) | .889 |
| AG/GG | 61 (42.1) | 36 (37.1) | 0.81 (0.479–1.37) | .441 | 0.87 (0.48–1.57) | .651 |
| A a | 227 (78.2) | 156 (81.2) | 1.0 (Ref.) | |||
| G a | 63 (21.8) | 36 (18.8) | 0.81 (0.47–1.37) | .441 | ||
| HWE | 0.060 | 0.540 | ||||
p < .025 (0.05/2) was significant after Bonferroni's correction.
a
Allele.
b
Adjusted for age, gender, diabetes and hypertension.
CI = confidence interval; OR = odds ratio; HWE = Hardy Weinberg equilibrium.