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. 2023 Jan 12;13:985538. doi: 10.3389/fimmu.2022.985538

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Copyright © 2023 Kaushik, Sahu, Guha, Saha, Das, Kupa, Kapfo, Deka, Basumatary, Thong, Dasgupta, Goswami, Pandey, Saikia, Khamo, Das and Nanda

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Perturbed iron homeostasis indicating iron sequestration observed in active tuberculosis (ATB) patients. Western blot images and densitometric value expression in ATB, non-tuberculosis (NTB), and healthy controls and in longitudinally followed up tuberculosis patients at case presentation (0 months) and upon completion of treatment (6 months) in inflammatory marker proteins (ceruloplasmin, ferritin, and hepcidin) (A), iron carrier proteins (transferrin and TfR) (B), iron-sensing proteins (hemojuvelin and IRP1) (C), and iron transporter proteins (ferroportin1, Nramp1, and Dmt1) (D) (P, patient; TfR, Transferrin receptor; IRP1, Iron regulatory protein 1; Nramp1, Natural resistance-associated macrophage protein 1; Dmt1, Divalent metal ion transporter 1; A.U., arbitrary unit; *p < 0.05; **p < 0.01).