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. 2023 Jan 12;13:1025346. doi: 10.3389/fpsyt.2022.1025346

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Copyright © 2023 Grimm, Mendez, Stertz, Meyer, Fries, Gandhi, Kanchi, Selvaraj, Teixeira, Kosten, Gunaratne, Coarfa and Walss-Bass.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulated miRNA–mRNA networks in brains from opioid use disorder (OUD) donors. Using the significant dysregulated protein coding genes measured in BA9, we determined enriched miRNA targets based on the OUD-associated miRNA candidates measured in panel (A) BA9 and (B) blood via the mirDB compendium. (C) Overlap of down regulated genes targeted by miRNAs in BA9 and blood. Network of genes targeted by miR-92a-3p is enlarged in panel (A).