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. 2023 Jan 12;13:1025346. doi: 10.3389/fpsyt.2022.1025346

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Copyright © 2023 Grimm, Mendez, Stertz, Meyer, Fries, Gandhi, Kanchi, Selvaraj, Teixeira, Kosten, Gunaratne, Coarfa and Walss-Bass.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation-based analysis of BA9 canonical miRNA–mRNA network genes. (A) Weighted gene correlation network analysis (WGCNA) was carried out for the 107 BA9 gene targets of BA9 miRNAs, identifying five distinct gene modules using a minimum module size of 5. The gray module of 26 uncorrelated genes was not included. (B) Association with brain cell type abundance (astrocytes, neurons, and endothelial cells) and OUD diagnosis was evaluated for each module. (C) Module membership is indicated in the network comprised of increased miRNAs and decreased genes, indicating the turquoise, blue, brown, green, and yellow WGCNA module genes.