FIGURE 6.

Gene set signatures for miRNA targets show robust and distinct correlation patterns. Gene signature scores were derived for opioid use disorder (OUD) down-regulated BA9 and blood miRNA targets, as well as for WGCNA modules, and comprehensive correlations were computed with the 50 Hallmark pathways over a collection of BA9 bulk tissue transcriptomes from 425 control brain samples from the GTEx project. Presented here is a subset of the Hallmark pathways, showing that OUD down-regulated targets of BA9 and blood miRNAs and the WGCNA turquoise module correlated with Hallmark pathways for Notch signaling, apoptosis, hypoxia, and TGFß signaling; WGCNA modules brown and blue correlated with immune system, inflammatory pathways, angiogenesis, and coagulation.