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. 2023 Jan 12;11:1042490. doi: 10.3389/fcell.2023.1042490

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Copyright © 2023 Ye, Zhong, Qian, Zhang, Xu, Han, Han, Wang, Song, Zeng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The correlation between BET genes expression and immune score was analyzed in TIMER and TISIDB database. (A) The heatmap of the correlation between BET genes and immune score in six types of immune cells. The different colors indicated different correlation coefficients (blue for positive correlation and red for negative correlation). (B) Relationships between the immune infiltration abundances and BRD4 expression in different immune cells (B-cell, CD4+T-cell, CD8+T-cell, neutrophils, macrophages and myeloid dendritic cells). (C) The correlations between expression of BRD4 and 28 types of TILs across human heterogeneous cancers. (D) BRD4 significantly negative correlated with abundance of activated CD8 T-cell (Act_CD8; rho = −0.445, p < 0.001). (E) BRD4 significantly negative correlated with abundance of effector memeory CD4 T-cell (Tem_CD4; rho = −0.496, p < 0.001).