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. 2023 Jan 10;17(2):896–909. doi: 10.1021/acsnano.2c05286

Figure 4.

Figure 4

PEP–TPP–mitochondria compound intravenously transplantation ameliorated myocardial IR injury in mice. (A) Schematic representation of the PEP–TPP–mitochondria compound intravenously transplantation strategy. (B) Echocardiography analyses of mice: sham (sham group), IR (IR injury group), IR + PEP-MITO (IR injury + PEP–TPP–mitochondrial transplantation group). (C) Ejection fraction and (D) fractional shortening mechanism. (E) Representative images of Evan’s blue and TTC staining. (F–H) Changes in infarction size induced by PEP–TPP–mitochondria compound transplantation. (I) Long-term analyses of ejection fraction and (J) fractional shortening in IR mice with or without PEP–TPP–mitochondria compound transplantation. Mean ± SEM, *P < 0.05, ***P < 0.001, ****P < 0.0001. Statistical analysis was carried out by a one-way ANOVA analysis followed by Tukey’s test for post hoc analysis.